Mika Aoyagi-Scharber Selected Research

alpha-N-acetyl-D-glucosaminidase (alpha-N-acetylglucosaminidase)

1/2020	Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B.
9/2019	Differential Uptake of NAGLU-IGF2 and Unmodified NAGLU in Cellular Models of Sanfilippo Syndrome Type B.
1/2019	BMN 250, a fusion of lysosomal alpha-N-acetylglucosaminidase with IGF2, exhibits different patterns of cellular uptake into critical cell types of Sanfilippo syndrome B disease pathogenesis.
9/2017	Clearance of Heparan Sulfate and Attenuation of CNS Pathology by Intracerebroventricular BMN 250 in Sanfilippo Type B Mice.
10/2014	Delivery of an enzyme-IGFII fusion protein to the mouse brain is therapeutic for mucopolysaccharidosis type IIIB.

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Mika Aoyagi-Scharber Research Topics

Disease

4	Mucopolysaccharidosis III (Sanfilippo Syndrome) 09/2019 - 10/2014
2	Mucopolysaccharidoses 09/2019 - 09/2017
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019 - 09/2017
2	Neoplasms (Cancer) 06/2015 - 09/2014
1	Rare Diseases (Rare Disease) 01/2020
1	Lysosomal Storage Diseases (Lysosomal Storage Disease) 09/2019
1	Breast Neoplasms (Breast Cancer) 01/2016
1	Achondroplasia 04/2015
1	Dwarfism 04/2015

Drug/Important Bio-Agent (IBA)

5	alpha-N-acetyl-D-glucosaminidase (alpha-N-acetylglucosaminidase)IBA 01/2020 - 10/2014
3	BMN 250IBA 01/2020 - 01/2019
3	Acetylglucosaminidase (NAGase)IBA 09/2019 - 10/2014
3	Heparitin Sulfate (Heparan Sulfate)IBA 01/2019 - 10/2014
2	EnzymesIBA 01/2020 - 10/2014
1	Recombinant Fusion ProteinsIBA 09/2019
1	Insulin-Like PeptidesIBA 09/2019
1	Cisplatin (Platino)FDA LinkGeneric 01/2016
1	Temozolomide (Temodar)FDA LinkGeneric 01/2016
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 06/2015
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 06/2015
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 04/2015
1	vosoritideIBA 04/2015
1	Neprilysin (Neutral Endopeptidase)IBA 04/2015
1	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 04/2015
1	C-Type Natriuretic Peptide (Peptide, C-Type Natriuretic)IBA 04/2015
1	Proteins (Proteins, Gene)FDA Link 10/2014
1	talazoparibIBA 09/2014

Therapy/Procedure

3	Enzyme Replacement Therapy 01/2020 - 10/2014
1	Drug Therapy (Chemotherapy) 01/2016
1	Oral Administration 01/2016
1	Therapeutics 06/2015